3qb5

X-ray diffraction
2.95Å resolution

Human C3PO complex in the presence of MnSO4

Released:
Source organism: Homo sapiens
Primary publication:
Structure of C3PO and mechanism of human RISC activation.
Nat Struct Mol Biol 18 650-7 (2011)
PMID: 21552258

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-172345 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Translin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 228 amino acids
Theoretical weight: 26.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15631 (Residues: 1-228; Coverage: 100%)
Gene name: TSN
Sequence domains: Translin family
Structure domains:
Translin-associated protein X Chain: K
Molecule details ›
Chain: K
Length: 290 amino acids
Theoretical weight: 33.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99598 (Residues: 1-290; Coverage: 100%)
Gene names: TRAX, TSNAX
Sequence domains: Translin family
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6122
Unit cell:
a: 98.166Å b: 98.166Å c: 446.466Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.226 0.224 0.273
Expression system: Escherichia coli BL21(DE3)