› 3qbj

X-ray diffraction
2.21Å resolution

Crystal structure of dipeptidyl peptidase IV in complex with inhibitor

Released:
DOI: 10.2210/pdb3qbj/pdb
PDB entry 3qbj coloured by chain, front view.
PDB entry 3qbj coloured by chain, side view.
PDB entry 3qbj coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Liu SP

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Dipeptidyl peptidase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 748 amino acids
Theoretical weight: 86.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P27487 (Residues: 31-766; Coverage: 96%)
Gene names: ADCP2, CD26, DPP4
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 3 x NAG
Ligand NXZ 2 x NXZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 65.751Å b: 69.082Å c: 424.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.236
Expression system: Spodoptera frugiperda

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