› 3qcw

X-ray diffraction
2.65Å resolution

Structure of neurexin 1 alpha (domains LNS1-LNS6), no splice inserts

Released:
DOI: 10.2210/pdb3qcw/pdb
PDB entry 3qcw coloured by chain, front view.
PDB entry 3qcw coloured by chain, side view.
PDB entry 3qcw coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The structure of neurexin 1α reveals features promoting a role as synaptic organizer.
Chen F, Venugopal V, Murray B, Rudenko G
Structure 19 779-89 (2011)
PMID: 21620716

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173308 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Neurexin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1245 amino acids
Theoretical weight: 137.47 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q28146 (Residues: 31-1359; Coverage: 83%)
Gene name: NRXN1
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P1
Unit cell:
a: 60.953Å b: 114.543Å c: 159.581Å
α: 90.61° β: 90.87° γ: 92.18°
R-values:
R R work R free
0.209 0.208 0.23
Expression system: Spodoptera frugiperda

Quick links

Citations

10 review citations

The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses.
Krueger et al. (2012)
9 more

10 mentions without citation

Neurexins - versatile molecular platforms in the synaptic cleft.
Rudenko G. (2019)
9 more