› 3qe1

X-ray diffraction
1.68Å resolution

Crystal Structure of PDZ domain of sorting nexin 27 (SNX27) fused to the C-terminal residues (ESESKV) of GIRK3

Released:
DOI: 10.2210/pdb3qe1/pdb
PDB entry 3qe1 coloured by chain, front view.
PDB entry 3qe1 coloured by chain, side view.
PDB entry 3qe1 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27.
Balana B, Maslennikov I, Kwiatkowski W, Stern KM, Bahima L, Choe S, Slesinger PA
Proc Natl Acad Sci U S A 108 5831-6 (2011)
PMID: 21422294

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179017 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
G protein-activated inward rectifier potassium channel 3; Sorting nexin-27 Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 11.23 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8K4V4 (Residues: 39-133; Coverage: 18%)
  • Canonical: Q63511 (Residues: 311-311; Coverage: 0%)
Gene names: Girk3, Kcnj9, Mrt1, Snx27
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: R3
Unit cell:
a: 75.789Å b: 75.789Å c: 40.939Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.161 0.158 0.223
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

20 review citations

Neurobiology of resilience.
Russo et al. (2012)
19 more

2 mentions without citation

Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27.
Balana et al. (2011)
1 more