› 3qek

X-ray diffraction
2Å resolution

Crystal structure of amino terminal domain of the NMDA receptor subunit GluN1

Released:
DOI: 10.2210/pdb3qek/pdb
PDB entry 3qek coloured by chain, front view.
PDB entry 3qek coloured by chain, side view.
PDB entry 3qek coloured by chain, top view.
Source organism: Xenopus laevis
Primary publication:
Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Karakas E, Simorowski N, Furukawa H
Nature 475 249-53 (2011)
PMID: 21677647

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-103587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glutamate receptor ionotropic, NMDA 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 384 amino acids
Theoretical weight: 43.44 KDa
Source organism: Xenopus laevis
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A1L8F5J9 (Residues: 23-190, 191-384; Coverage: 41%)
Gene name: grin1
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand K 2 x K
Ligand NAG 4 x NAG
1 modified residue:
Ligand MSE 18 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 47.323Å b: 92.813Å c: 209.978Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.226
Expression system: Trichoplusia ni

Quick links

Citations

41 review citations

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease.
Paoletti et al. (2013)
40 more

2 mentions without citation

Functional insights from glutamate receptor ion channel structures.
Kumar et al. (2013)
1 more