› 3qln

X-ray diffraction
1.9Å resolution

Crystal structure of ATRX ADD domain in free state

Released:
DOI: 10.2210/pdb3qln/pdb
PDB entry 3qln coloured by chain, front view.
PDB entry 3qln coloured by chain, side view.
PDB entry 3qln coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome.
Iwase S, Xiang B, Ghosh S, Ren T, Lewis PW, Cochrane JC, Allis CD, Picketts DJ, Patel DJ, Li H, Shi Y
Nat Struct Mol Biol 18 769-76 (2011)
PMID: 21666679

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155427 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional regulator ATRX Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 14.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46100 (Residues: 167-289; Coverage: 5%)
Gene names: ATRX, RAD54L, XH2
Sequence domains: Cysteine Rich ADD domain

Ligands and Environments

1 bound ligand:
Ligand ZN 6 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P32
Unit cell:
a: 74.167Å b: 74.167Å c: 54.091Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.13 0.127 0.158
Expression system: Escherichia coli

Quick links

Citations

70 review citations

Histone methylation: a dynamic mark in health, disease and inheritance.
Greer et al. (2012)
69 more

1 mention without citation

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome.
Iwase et al. (2011)