Function and Biology Details
Reaction catalysed:
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- P-loop containing nucleoside triphosphate hydrolase
- AAA+ ATPase domain
- Glutathione S-transferase, N-terminal
- Glutathione S-transferase, C-terminal
- Glutathione S-transferase, C-terminal-like
- Glutathione S-transferase, C-terminal domain superfamily
- Thioredoxin-like superfamily
- Dynein heavy chain AAA lid domain
11 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140159 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dynein heavy chain, cytoplasmic
Molecule details ›
Chains: A, B
Length: 2486 amino acids
Theoretical weight: 285.68 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 2486 amino acids
Theoretical weight: 285.68 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
P36022 (Residues: 1364-4092; Coverage: 61%)
Sequence domains:
- Dynein heavy chain, N-terminal region 2
- Hydrolytic ATP binding site of dynein motor region
- DYN1, AAA+ ATPase lid domain
- P-loop containing dynein motor region
- AAA+ lid domain
- P-loop containing dynein motor region D4
- Microtubule-binding stalk of dynein motor
- ATP-binding dynein motor region
- Dynein heavy chain region D6 P-loop domain
- Dynein heavy chain AAA lid domain
Glutathione S-transferase class-mu 26 kDa isozyme
Molecule details ›
Chains: S, T
Length: 219 amino acids
Theoretical weight: 25.61 KDa
Source organism: Schistosoma japonicum
Expression system: Saccharomyces cerevisiae
UniProt:
Length: 219 amino acids
Theoretical weight: 25.61 KDa
Source organism: Schistosoma japonicum
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical: P08515 (Residues: 2-218; Coverage: 100%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 8.3.1, null
Spacegroup:
P21
Expression system: Saccharomyces cerevisiae
