› 3qo1

X-ray diffraction
2.4Å resolution

Monoclinic form of IgG1 Fab fragment (apo form) sharing same Fv as IgA

Released:
DOI: 10.2210/pdb3qo1/pdb
PDB entry 3qo1 coloured by chain, front view.
PDB entry 3qo1 coloured by chain, side view.
PDB entry 3qo1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulation.
Correa A, Trajtenberg F, Obal G, Pritsch O, Dighiero G, Oppezzo P, Buschiazzo A
Acta Crystallogr D Biol Crystallogr 69 388-97 (2013)
PMID: 23519414

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-234876 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fab fragment of IMMUNOGLOBULIN G1 LIGHT CHAIN Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 24.01 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Fab fragment of IMMUNOGLOBULIN G1 HEAVY CHAIN Chain: B
Molecule details ›
Chain: B
Length: 220 amino acids
Theoretical weight: 23.2 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 53.297Å b: 67.214Å c: 68.952Å
α: 90° β: 103.39° γ: 90°
R-values:
R R work R free
0.169 0.166 0.224

Quick links

Citations

6 review citations

Ig Constant Region Effects on Variable Region Structure and Function.
Janda et al. (2016)
5 more

1 mention without citation

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody.
Ishchenko et al. (2017)