› 3qp6

X-ray diffraction
2Å resolution

Crystal structure of CviR (Chromobacterium violaceum 12472) bound to C6-HSL

Released:
DOI: 10.2210/pdb3qp6/pdb
PDB entry 3qp6 coloured by chain, front view.
PDB entry 3qp6 coloured by chain, side view.
PDB entry 3qp6 coloured by chain, top view.
Source organism: Chromobacterium violaceum
Primary publication:
A strategy for antagonizing quorum sensing.
Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, Bassler BL, Hughson FM
Mol Cell 42 199-209 (2011)
PMID: 21504831

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181817 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH luxR-type domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 29.56 KDa
Source organism: Chromobacterium violaceum
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7NQP7 (Residues: 1-265; Coverage: 100%)
Gene names: CV_4090, cviR
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand HL6 1 x HL6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2221
Unit cell:
a: 50.248Å b: 89.12Å c: 132.125Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.183 0.224
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

33 review citations

Quorum sensing signal-response systems in Gram-negative bacteria.
Papenfort et al. (2016)
32 more

20 mentions without citation

Can the natural diversity of quorum-sensing advance synthetic biology?
Davis et al. (2015)
19 more