› 3qq3

X-ray diffraction
2.59Å resolution

Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides

Released:
DOI: 10.2210/pdb3qq3/pdb
PDB entry 3qq3 coloured by chain, front view.
PDB entry 3qq3 coloured by chain, side view.
PDB entry 3qq3 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides.
Zhang N, Qi J, Feng S, Gao F, Liu J, Pan X, Chen R, Li Q, Chen Z, Li X, Xia C, Gao GF
J Virol 85 11709-24 (2011)
PMID: 21900158

Function and Biology Details

Reaction catalysed: 
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-127598 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chains: A, D
Molecule details ›
Chains: A, D
Length: 275 amino acids
Theoretical weight: 31.68 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: O19244 (Residues: 22-296; Coverage: 81%)
Gene names: PD1, SLA-1
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.71 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07717 (Residues: 21-118; Coverage: 100%)
Gene name: B2M
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Neuraminidase Chains: C, F
Molecule details ›
Chains: C, F
Length: 9 amino acids
Theoretical weight: 1.05 KDa
Source organism: Influenza A virus
Expression system: Not provided
UniProt:
  • Canonical: Q9Q0U7 (Residues: 449-457; Coverage: 2%)
Gene name: NA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 96.731Å b: 37.651Å c: 111.43Å
α: 90° β: 113.06° γ: 90°
R-values:
R R work R free
0.203 0.2 0.262
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

The pig: a model for human infectious diseases.
Meurens et al. (2012)
2 more

21 mentions without citation

The Function of the PRRSV-Host Interactions and Their Effects on Viral Replication and Propagation in Antiviral Strategies.
Ma et al. (2021)
20 more