› 3qrb

X-ray diffraction
1.8Å resolution

crystal structure of E-cadherin EC1-2 P5A P6A

Released:
DOI: 10.2210/pdb3qrb/pdb
PDB entry 3qrb coloured by chain, front view.
PDB entry 3qrb coloured by chain, side view.
PDB entry 3qrb coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins.
Vendome J, Posy S, Jin X, Bahna F, Ahlsen G, Shapiro L, Honig B
Nat Struct Mol Biol 18 693-700 (2011)
PMID: 21572446

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140757 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 213 amino acids
Theoretical weight: 23.21 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P09803 (Residues: 157-369; Coverage: 25%)
Gene name: Cdh1
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

3 bound ligands:
Ligand CA 6 x CA
Ligand EDO 4 x EDO
Ligand PGE 2 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2
Unit cell:
a: 111.185Å b: 92.583Å c: 79.465Å
α: 90° β: 92.26° γ: 90°
R-values:
R R work R free
0.162 0.162 0.178
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Thinking outside the cell: how cadherins drive adhesion.
Brasch et al. (2012)
9 more

1 mention without citation

Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins.
Vendome et al. (2011)