› 3qyb

X-ray diffraction
3.5Å resolution

X-ray Crystal Structure of Human TBC1D4 (AS160) RabGAP domain

Released:
DOI: 10.2210/pdb3qyb/pdb
PDB entry 3qyb coloured by chain, front view.
PDB entry 3qyb coloured by chain, side view.
PDB entry 3qyb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
Park SY, Jin W, Woo JR, Shoelson SE
J Biol Chem 286 18130-8 (2011)
PMID: 21454505

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129970 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TBC1 domain family member 4 Chain: A
Molecule details ›
Chain: A
Length: 301 amino acids
Theoretical weight: 35.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60343 (Residues: 874-1170; Coverage: 23%)
Gene names: AS160, KIAA0603, TBC1D4
Sequence domains: Rab-GTPase-TBC domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P3221
Unit cell:
a: 151.214Å b: 151.214Å c: 53.155Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.246 0.3
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Molecular control of Rab activity by GEFs, GAPs and GDI.
Müller et al. (2018)
15 other articles

4 mentions without citation

TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells.
Gallo et al. (2014)
3 more