› 3rbn

X-ray diffraction
2.16Å resolution

Crystal structure of MutL protein homolog 1 isoform 1 [Homo sapiens]

Released:
DOI: 10.2210/pdb3rbn/pdb
PDB entry 3rbn coloured by chain, front view.
PDB entry 3rbn coloured by chain, side view.
PDB entry 3rbn coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Dombrovsky L, Wernimont A, Loppnau P, Bountra C, Weigelt J, Arrowsmith CH, Edwards AM, Min J, Wu H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154160 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA mismatch repair protein Mlh1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 284 amino acids
Theoretical weight: 33.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P40692 (Residues: 486-751; Coverage: 35%)
Gene names: COCA2, MLH1
Sequence domains: DNA mismatch repair protein Mlh1 C-terminus

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 63.505Å b: 64.7Å c: 130.932Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.208 0.251
Expression system: Escherichia coli BL21(DE3)

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