› 3rbw

X-ray diffraction
3.2Å resolution

Crystal structure of Spire KIND domain

Released:
DOI: 10.2210/pdb3rbw/pdb
PDB entry 3rbw coloured by chain, front view.
PDB entry 3rbw coloured by chain, side view.
PDB entry 3rbw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Spire KIND domain and insights into its interaction with Fmn-family formins
Vizcarra C, Kreutz B, Rodal A, Toms A, Lu J, Zheng W, Quinlan M, Eck M
Proc. Natl. Acad. Sci. U.S.A. (2011)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170713 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein spire homolog 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 220 amino acids
Theoretical weight: 24.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q08AE8 (Residues: 20-237; Coverage: 29%)
Gene names: KIAA1135, SPIR1, SPIRE1
Sequence domains: Kinase non-catalytic C-lobe domain
Structure domains: Transferase(Phosphotransferase) domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 73.328Å b: 66.265Å c: 100.852Å
α: 90° β: 103° γ: 90°
R-values:
R R work R free
0.263 0.261 0.315
Expression system: Escherichia coli

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