› 3rjr

X-ray diffraction
3.05Å resolution

Crystal Structure of pro-TGF beta 1

Released:
DOI: 10.2210/pdb3rjr/pdb
PDB entry 3rjr coloured by chain, front view.
PDB entry 3rjr coloured by chain, side view.
PDB entry 3rjr coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Latent TGF-β structure and activation.
Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA
Nature 474 343-9 (2011)
PMID: 21677751

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139429 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Transforming growth factor beta-1 proprotein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 363 amino acids
Theoretical weight: 41.43 KDa
Source organism: Sus scrofa
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P07200 (Residues: 30-390; Coverage: 100%)
Gene name: TGFB1
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 54.69Å b: 126.94Å c: 137.93Å
α: 90° β: 96.72° γ: 90°
R-values:
R R work R free
0.275 0.274 0.311
Expression system: Cricetulus griseus

Quick links

Citations

219 review citations

TGFβ signalling in context.
Massagué J. (2012)
218 more

29 mentions without citation

Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation.
Walker et al. (2016)
28 more