› 3rlo

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172551 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-interferon-inducible protein 16 Chain: A
Molecule details ›
Chain: A
Length: 204 amino acids
Theoretical weight: 22.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16666 (Residues: 571-766; Coverage: 25%)
Gene names: IFI16, IFNGIP1
Sequence domains: HIN-200/IF120x domain
Structure domains: Nucleic acid-binding proteins

Ligands and Environments

2 bound ligands:
Ligand EDO 9 x EDO
Ligand FMT 1 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: R32
Unit cell:
a: 128.562Å b: 128.562Å c: 67.743Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.169 0.168 0.192
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

180 review citations

Activation and regulation of the inflammasomes.
Latz et al. (2013)
179 more

5 mentions without citation

Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Jin et al. (2012)
4 more