› 3roe

X-ray diffraction
2.11Å resolution

Crystal Structure of Mouse Apolipoprotein A-I Binding Protein in Complex with Thymidine

Released:
DOI: 10.2210/pdb3roe/pdb
PDB entry 3roe coloured by chain, front view.
PDB entry 3roe coloured by chain, side view.
PDB entry 3roe coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Identification of unknown protein function using metabolite cocktail screening.
Shumilin IA, Cymborowski M, Chertihin O, Jha KN, Herr JC, Lesley SA, Joachimiak A, Minor W
Structure 20 1715-25 (2012)
PMID: 22940582

Function and Biology Details

Reaction catalysed: 
(6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185092 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD(P)H-hydrate epimerase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 265 amino acids
Theoretical weight: 29.87 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8K4Z3 (Residues: 25-282; Coverage: 92%)
Gene names: Aibp, Apoa1bp, Naxe
Sequence domains: YjeF-related protein N-terminus
Structure domains: YjeF N-terminal domain

Ligands and Environments

1 bound ligand:
Ligand THM 6 x THM
1 modified residue:
Ligand MSE 48 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: C2
Unit cell:
a: 106.209Å b: 124.446Å c: 164.249Å
α: 90° β: 102.71° γ: 90°
R-values:
R R work R free
0.178 0.177 0.211
Expression system: Escherichia coli

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Citations

11 review citations

Zebrafish models of dyslipidemia: relevance to atherosclerosis and angiogenesis.
Fang et al. (2014)
10 more