› 3rrt

X-ray diffraction
3.2Å resolution

Structure of the RSV F protein in the post-fusion conformation

Released:
DOI: 10.2210/pdb3rrt/pdb
PDB entry 3rrt coloured by chain, front view.
PDB entry 3rrt coloured by chain, side view.
PDB entry 3rrt coloured by chain, top view.
Source organism: Human orthopneumovirus
Primary publication:
Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes.
McLellan JS, Yang Y, Graham BS, Kwong PD
J Virol 85 7788-96 (2011)
PMID: 21613394

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136983 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fusion glycoprotein F2 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 84 amino acids
Theoretical weight: 9.53 KDa
Source organism: Human orthopneumovirus
Expression system: Homo sapiens
UniProt:
  • Canonical: P03420 (Residues: 26-109; Coverage: 15%)
Gene name: F
Structure domains:
Fusion glycoprotein F1 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 374 amino acids
Theoretical weight: 41.32 KDa
Source organism: Human orthopneumovirus
Expression system: Homo sapiens
UniProt:
  • Canonical: P03420 (Residues: 147-513; Coverage: 67%)
Gene name: F
Sequence domains: Fusion glycoprotein F0

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 71.024Å b: 81.877Å c: 271.948Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.255 0.253 0.282
Expression system: Homo sapiens

Quick links

Citations

73 review citations

Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years.
Collins et al. (2011)
72 more

17 mentions without citation

Timing is everything: Fine-tuned molecular machines orchestrate paramyxovirus entry.
Bose et al. (2015)
16 more