› 3ry8

X-ray diffraction
1.4Å resolution

Structural basis for norovirus inhibition and fucose mimicry by citrate

Released:
DOI: 10.2210/pdb3ry8/pdb
PDB entry 3ry8 coloured by chain, front view.
PDB entry 3ry8 coloured by chain, side view.
PDB entry 3ry8 coloured by chain, top view.
Source organism: Norwalk virus
Primary publication:
Structural basis for norovirus inhibition and fucose mimicry by citrate.
Hansman GS, Shahzad-Ul-Hussan S, McLellan JS, Chuang GY, Georgiev I, Shimoike T, Katayama K, Bewley CA, Kwong PD
J Virol 86 284-92 (2012)
PMID: 22031945

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177037 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 319 amino acids
Theoretical weight: 34.8 KDa
Source organism: Norwalk virus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5F4T5 (Residues: 225-538; Coverage: 57%)
Sequence domains: Calicivirus coat protein C-terminal
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 11 x EDO
Ligand FLC 1 x FLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21
Unit cell:
a: 63.763Å b: 79.811Å c: 69.605Å
α: 90° β: 96.84° γ: 90°
R-values:
R R work R free
0.139 0.139 0.151
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

Foodborne viruses: Detection, risk assessment, and control options in food processing.
Bosch et al. (2018)
14 more

2 mentions without citation

Progress towards the prevention and treatment of norovirus infections.
Arias et al. (2013)
1 more