› 3rzf

X-ray diffraction
4Å resolution

Crystal Structure of Inhibitor of kappaB kinase beta (I4122)

Released:
DOI: 10.2210/pdb3rzf/pdb
PDB entry 3rzf coloured by chain, front view.
PDB entry 3rzf coloured by chain, side view.
PDB entry 3rzf coloured by chain, top view.
Source organism: Xenopus laevis
Primary publication:
Crystal structure of inhibitor of κB kinase β.
Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H
Nature 472 325-30 (2011)
PMID: 21423167

Function and Biology Details

Reaction catalysed: 
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179763 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
IkappaB kinase Chain: A
Molecule details ›
Chain: A
Length: 677 amino acids
Theoretical weight: 78 KDa
Source organism: Xenopus laevis
UniProt:
  • Canonical: Q6INT1 (Residues: 1-659; Coverage: 89%)
Gene names: MGC80376, ikbkb, ikbkb.L, ikk-beta, ikk2, ikkb, ikkbeta
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand XNM 1 x XNM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: I4122
Unit cell:
a: 164.656Å b: 164.656Å c: 273.458Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.273 0.27 0.34

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Citations

24 review citations

NF-κB, inflammation, immunity and cancer: coming of age.
Taniguchi et al. (2018)
23 more

32 mentions without citation

Copaifera of the Neotropics: A Review of the Phytochemistry and Pharmacology.
da Trindade et al. (2018)
31 more