› 3s0k

X-ray diffraction
1.4Å resolution

Crystal Structure of Human Glycolipid Transfer Protein complexed with glucosylceramide containing oleoyl acyl chain (18:1)

Released:
DOI: 10.2210/pdb3s0k/pdb
PDB entry 3s0k coloured by chain, front view.
PDB entry 3s0k coloured by chain, side view.
PDB entry 3s0k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Enhanced selectivity for sulfatide by engineered human glycolipid transfer protein.
Samygina VR, Popov AN, Cabo-Bilbao A, Ochoa-Lizarralde B, Goni-de-Cerio F, Zhai X, Molotkovsky JG, Patel DJ, Brown RE, Malinina L
Structure 19 1644-54 (2011)
PMID: 22078563

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192739 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycolipid transfer protein Chain: A
Molecule details ›
Chain: A
Length: 209 amino acids
Theoretical weight: 23.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZD2 (Residues: 1-209; Coverage: 100%)
Gene name: GLTP
Sequence domains: Glycolipid transfer protein (GLTP)
Structure domains: Glycolipid transfer protein

Ligands and Environments

2 bound ligands:
Ligand 03F 1 x 03F
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 50.659Å b: 61.646Å c: 67.214Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.152 0.15 0.182
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Sphingolipids and their metabolism in physiology and disease.
Hannun et al. (2018)
5 more

7 mentions without citation

How α-Helical Motifs Form Functionally Diverse Lipid-Binding Compartments.
Malinina et al. (2017)
6 more