› 3s69

X-ray diffraction
1.43Å resolution

Crystal structure of saxthrombin

Released:
DOI: 10.2210/pdb3s69/pdb
PDB entry 3s69 coloured by chain, front view.
PDB entry 3s69 coloured by chain, side view.
PDB entry 3s69 coloured by chain, top view.
Source organism: Gloydius saxatilis
Primary publication:
Structure of saxthrombin, a thrombin-like enzyme from Gloydius saxatilis.
Huang K, Zhao W, Gao Y, Wei W, Teng M, Niu L
Acta Crystallogr Sect F Struct Biol Cryst Commun 67 862-5 (2011)
PMID: 21821882

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181995 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thrombin-like enzyme saxthrombin Chain: A
Molecule details ›
Chain: A
Length: 234 amino acids
Theoretical weight: 25.5 KDa
Source organism: Gloydius saxatilis
UniProt:
  • Canonical: Q7SZE1 (Residues: 25-258; Coverage: 98%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: C2
Unit cell:
a: 97.234Å b: 52.208Å c: 50.103Å
α: 90° β: 96.72° γ: 90°
R-values:
R R work R free
0.19 0.189 0.202

Quick links

Citations

5 citation in other articles

Crystal structure and activating effect on RyRs of AhV_TL-I, a glycosylated thrombin-like enzyme from Agkistrodon halys snake venom.
Zeng et al. (2013)
4 more

3 mentions without citation

The chemistry of snake venom and its medicinal potential.
Oliveira et al. (2022)
2 more