› 3s6w

X-ray diffraction
1.78Å resolution

Crystal structure of Tudor domain of human TDRD3

Released:
DOI: 10.2210/pdb3s6w/pdb
PDB entry 3s6w coloured by chain, front view.
PDB entry 3s6w coloured by chain, side view.
PDB entry 3s6w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30.
Liu K, Guo Y, Liu H, Bian C, Lam R, Liu Y, Mackenzie F, Rojas LA, Reinberg D, Bedford MT, Xu RM, Min J
PLoS One 7 e30375 (2012)
PMID: 22363433

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190662 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tudor domain-containing protein 3 Chain: A
Molecule details ›
Chain: A
Length: 54 amino acids
Theoretical weight: 6.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H7E2 (Residues: 555-608; Coverage: 8%)
Gene name: TDRD3
Sequence domains: Tudor domain
Structure domains: SH3 type barrels.

Ligands and Environments

1 bound ligand:
Ligand IPA 2 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P65
Unit cell:
a: 41.93Å b: 41.93Å c: 61.478Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.183 0.206
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Protein arginine methyltransferases and cancer.
Yang et al. (2013)
17 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)