› 3s7c

X-ray diffraction
1.1Å resolution

Crystal structure of a 2'-azido-uridine-modified RNA

Released:
DOI: 10.2210/pdb3s7c/pdb
PDB entry 3s7c coloured by chain, front view.
PDB entry 3s7c coloured by chain, side view.
PDB entry 3s7c coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
2'-Azido RNA, a versatile tool for chemical biology: synthesis, X-ray structure, siRNA applications, click labeling.
Fauster K, Hartl M, Santner T, Aigner M, Kreutz C, Bister K, Ennifar E, Micura R
ACS Chem Biol 7 581-9 (2012)
PMID: 22273279

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196729 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
Ecoli 23 S rRNA Sarcin Ricin loop Chain: A
Molecule details ›
Chain: A
Length: 27 nucleotides
Theoretical weight: 8.77 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P43
Unit cell:
a: 29.61Å b: 29.61Å c: 76.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.118 0.117 0.156
Expression system: Not provided

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Citations

15 review citations

Designing chemically modified oligonucleotides for targeted gene silencing.
Deleavey et al. (2012)
14 more