› 3se8

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211966 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Envelope glycoprotein gp160 Chain: G
Molecule details ›
Chain: G
Length: 353 amino acids
Theoretical weight: 39.21 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q0ED31 (Residues: 43-486; Coverage: 41%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
Heavy chain of antibody VRC03 Chain: H
Molecule details ›
Chain: H
Length: 233 amino acids
Theoretical weight: 25.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Light chain of antibody VRC03 Chain: L
Molecule details ›
Chain: L
Length: 209 amino acids
Theoretical weight: 23.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

4 bound ligands:
Ligand NAG 11 x NAG
Ligand SO4 8 x SO4
Ligand EDO 2 x EDO
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 62.01Å b: 70.259Å c: 217.879Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.233
Expression system: Homo sapiens

Quick links

Citations

148 review citations

Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies.
Kwong et al. (2012)
147 more

30 mentions without citation

HIV-1 envelope glycoprotein structure.
Merk et al. (2013)
29 more