› 3sen

X-ray diffraction
3.1Å resolution

Structure of Caskin1 Tandem SAMs

Released:
DOI: 10.2210/pdb3sen/pdb
PDB entry 3sen coloured by chain, front view.
PDB entry 3sen coloured by chain, side view.
PDB entry 3sen coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK.
Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU
Structure 19 1826-36 (2011)
PMID: 22153505

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186772 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caskin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 157 amino acids
Theoretical weight: 17.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WXD9 (Residues: 470-613; Coverage: 10%)
Gene names: CASKIN1, KIAA1306
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

1 bound ligand:
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 92.226Å b: 94.597Å c: 118.633Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.24 0.282
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Hunting for Novel Routes in Anticancer Drug Discovery: Peptides against Sam-Sam Interactions.
Mercurio et al. (2022)
15 other articles

5 mentions without citation

The Structural Dynamics, Complexity of Interactions, and Functions in Cancer of Multi-SAM Containing Proteins.
Clements et al. (2023)
4 more