› 3sgd

X-ray diffraction
2.31Å resolution

Crystal structure of the mouse mAb 17.2

Released:
DOI: 10.2210/pdb3sgd/pdb
Model geometry
Fit model/data
PDB entry 3sgd coloured by chain, front view.
PDB entry 3sgd coloured by chain, side view.
PDB entry 3sgd coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of the complex mAb 17.2 and the C-terminal region of Trypanosoma cruzi P2β protein: implications in cross-reactivity.
Pizarro JC, Boulot G, Bentley GA, Gómez KA, Hoebeke J, Hontebeyrie M, Levin MJ, Smulski CR
OpenAccess logo PLoS Negl Trop Dis 5 e1375 (2011)
PMID: 22069505

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213397 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Light Chain Chains: I, L
Molecule details ›
Chains: I, L
Length: 219 amino acids
Theoretical weight: 24.18 KDa
Source organism: Mus musculus
Expression system: Not provided
Structure domains: Immunoglobulins
Heavy Chain Chains: H, J
Molecule details ›
Chains: H, J
Length: 217 amino acids
Theoretical weight: 23.54 KDa
Source organism: Mus musculus
Expression system: Not provided
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P21
Unit cell:
a: 81.76Å b: 65.46Å c: 91.03Å
α: 90° β: 98.18° γ: 90°
R-values:
R R work R free
0.176 0.172 0.236
Expression system: Not provided

Quick links

Citations

1 review citation

Targeting anti-beta-1-adrenergic receptor antibodies for dilated cardiomyopathy.
Patel et al. (2013)
3 other articles

5 mentions without citation

Engineering a high-affinity humanized anti-CD24 antibody to target hepatocellular carcinoma by a novel CDR grafting design.
Sun et al. (2017)
4 more