› 3sh3

X-ray diffraction
2.3Å resolution

Crystal structure of a pro-inflammatory lectin from the seeds of Dioclea wilsonii STANDL

Released:
DOI: 10.2210/pdb3sh3/pdb
PDB entry 3sh3 coloured by chain, front view.
PDB entry 3sh3 coloured by chain, side view.
PDB entry 3sh3 coloured by chain, top view.
Source organism: Macropsychanthus wilsonii
Primary publication:
Crystal structure of a pro-inflammatory lectin from the seeds of Dioclea wilsonii Standl.
Rangel TB, Rocha BA, Bezerra GA, Assreuy AM, Pires Ade F, do Nascimento AS, Bezerra MJ, do Nascimento KS, Nagano CS, Sampaio AH, Gruber K, Delatorre P, Fernandes PM, Cavada BS
Biochimie 94 525-32 (2012)
PMID: 21924319

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160981 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lectin alpha chain Chain: A
Molecule details ›
Chain: A
Length: 237 amino acids
Theoretical weight: 25.66 KDa
Source organism: Macropsychanthus wilsonii
UniProt:
  • Canonical: P86624 (Residues: 1-237; Coverage: 100%)
Sequence domains: Legume lectin domain
Structure domains: Jelly Rolls

Ligands and Environments

5 bound ligands:
Ligand MN 1 x MN
Ligand CA 1 x CA
Ligand XMM 1 x XMM
Ligand CL 1 x CL
Ligand A3B 1 x A3B
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: I222
Unit cell:
a: 58.82Å b: 66.873Å c: 107.345Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.262

Quick links

Citations

1 review citation

Overview of the Structure⁻Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi.
Barre et al. (2019)
11 other articles

8 mentions without citation

ConA-Like Lectins: High Similarity Proteins as Models to Study Structure/Biological Activities Relationships.
Cavada et al. (2018)
7 more