› 3sj2

X-ray diffraction
1.36Å resolution

A Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X Syndrome

Released:
DOI: 10.2210/pdb3sj2/pdb
PDB entry 3sj2 coloured by chain, front view.
PDB entry 3sj2 coloured by chain, side view.
PDB entry 3sj2 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome.
Kumar A, Fang P, Park H, Guo M, Nettles KW, Disney MD
Chembiochem 12 2140-2 (2011)
PMID: 21766409

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196731 (preferred)
Entry contents:
2 distinct RNA molecules
Macromolecules (2 distinct):
RNA (5'-R(*UP*UP*GP*GP*GP*CP*CP*GP*GP*CP*GP*GP*CP*GP*GP*GP*UP*CP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 19 nucleotides
Theoretical weight: 6.16 KDa
Source organism: Synthetic construct
Expression system: Not provided
RNA (5'-R(P*GP*GP*GP*CP*CP*GP*GP*CP*GP*GP*CP*GP*GP*GP*UP*CP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 17 nucleotides
Theoretical weight: 5.54 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2
Unit cell:
a: 55.66Å b: 32.32Å c: 69.442Å
α: 90° β: 108.95° γ: 90°
R-values:
R R work R free
0.157 0.154 0.185
Expression system: Not provided

Quick links

Citations

5 review citations

Methods to enable the design of bioactive small molecules targeting RNA.
Disney et al. (2014)
4 more

4 mentions without citation

RNA Structures as Mediators of Neurological Diseases and as Drug Targets.
Bernat et al. (2015)
3 more