› 3slz

X-ray diffraction
1.4Å resolution

The crystal structure of XMRV protease complexed with TL-3

Released:
DOI: 10.2210/pdb3slz/pdb
PDB entry 3slz coloured by chain, front view.
PDB entry 3slz coloured by chain, side view.
PDB entry 3slz coloured by chain, top view.
Source organism: DG-75 Murine leukemia virus
Primary publication:
Structural and biochemical characterization of the inhibitor complexes of xenotropic murine leukemia virus-related virus protease.
Li M, Gustchina A, Matúz K, Tözsér J, Namwong S, Goldfarb NE, Dunn BM, Wlodawer A
FEBS J 278 4413-24 (2011)
PMID: 21951660

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190134 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
gag-pro-pol polyprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 132 amino acids
Theoretical weight: 14.35 KDa
Source organism: DG-75 Murine leukemia virus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9E7M1 (Residues: 533-657; Coverage: 7%)
Sequence domains: Retroviral aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

3 bound ligands:
Ligand 3TL 1 x 3TL
Ligand FMT 6 x FMT
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 46.483Å b: 65.546Å c: 69.732Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.176 0.201
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 citation in other articles

Biochemical characterization of Ty1 retrotransposon protease.
Gazda et al. (2020)
5 more

2 mentions without citation

Dimer Interface Organization is a Main Determinant of Intermonomeric Interactions and Correlates with Evolutionary Relationships of Retroviral and Retroviral-Like Ddi1 and Ddi2 Proteases.
Mótyán et al. (2020)
1 more