› 3so6

X-ray diffraction
1.37Å resolution

Crystal structure of the LDL receptor tail in complex with autosomal recessive hypercholesterolemia PTB domain

Released:
DOI: 10.2210/pdb3so6/pdb
PDB entry 3so6 coloured by chain, front view.
PDB entry 3so6 coloured by chain, side view.
PDB entry 3so6 coloured by chain, top view.
Source organisms:
Primary publication:
Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.
Dvir H, Shah M, Girardi E, Guo L, Farquhar MG, Zajonc DM
Proc Natl Acad Sci U S A 109 6916-21 (2012)
PMID: 22509010

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112597 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Low density lipoprotein receptor adapter protein 1 Chain: A
Molecule details ›
Chain: A
Length: 137 amino acids
Theoretical weight: 15.27 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: D3ZAR1 (Residues: 43-120, 121-173; Coverage: 43%)
Gene names: Arh, Ldlrap1
Sequence domains: Phosphotyrosine interaction domain (PTB/PID)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Low-density lipoprotein receptor Chain: Q
Molecule details ›
Chain: Q
Length: 14 amino acids
Theoretical weight: 1.64 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01130 (Residues: 819-832; Coverage: 2%)
Gene name: LDLR

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 29.097Å b: 59.095Å c: 77.083Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.152 0.206
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

Disabled-2: A modular scaffold protein with multifaceted functions in signaling.
Finkielstein et al. (2016)
2 more

11 mentions without citation

Molecular structure, function, and dynamics of clathrin-mediated membrane traffic.
Kirchhausen et al. (2014)
10 more