› 3svg

X-ray diffraction
1.68Å resolution

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand

Released:
DOI: 10.2210/pdb3svg/pdb
PDB entry 3svg coloured by chain, front view.
PDB entry 3svg coloured by chain, side view.
PDB entry 3svg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Picaud S, Felletar I, Hewings SD, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Conway SJ, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand EDO 3 x EDO
Ligand ODR 1 x ODR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 37.66Å b: 44.19Å c: 77.85Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.215
Expression system: Escherichia coli

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