› 3swh

X-ray diffraction
2.65Å resolution

Munc13-1, MUN domain, C-terminal module

Released:
DOI: 10.2210/pdb3swh/pdb
PDB entry 3swh coloured by chain, front view.
PDB entry 3swh coloured by chain, side view.
PDB entry 3swh coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors.
Li W, Ma C, Guan R, Xu Y, Tomchick DR, Rizo J
Structure 19 1443-55 (2011)
PMID: 22000513

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178967 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein unc-13 homolog A Chains: A, B
Molecule details ›
Chains: A, B
Length: 341 amino acids
Theoretical weight: 38.74 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q62768 (Residues: 1148-1407, 1453-1531; Coverage: 20%)
Gene names: Unc13a, Unc13h1
Sequence domains: MUN domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P42
Unit cell:
a: 160.791Å b: 160.791Å c: 42.239Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.244 0.302
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

22 review citations

The presynaptic active zone.
Südhof TC. (2012)
21 more

5 mentions without citation

Structures and mechanisms of vesicle coat components and multisubunit tethering complexes.
Jackson et al. (2012)
4 more