› 3tbk

X-ray diffraction
2.14Å resolution

Mouse RIG-I ATPase Domain

Released:
DOI: 10.2210/pdb3tbk/pdb
PDB entry 3tbk coloured by chain, front view.
PDB entry 3tbk coloured by chain, side view.
PDB entry 3tbk coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling.
Civril F, Bennett M, Moldt M, Deimling T, Witte G, Schiesser S, Carell T, Hopfner KP
EMBO Rep 12 1127-34 (2011)
PMID: 21979817

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180247 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antiviral innate immune response receptor RIG-I Chain: A
Molecule details ›
Chain: A
Length: 555 amino acids
Theoretical weight: 63.47 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6Q899 (Residues: 240-794; Coverage: 60%)
Gene names: Ddx58, Rigi
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ANP 1 x ANP
Ligand EDO 1 x EDO
1 modified residue:
Ligand MSE 11 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 46.144Å b: 86.027Å c: 153.097Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.187 0.236
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Coronavirus infections and immune responses.
Li et al. (2020)
24 more

6 mentions without citation

Structural insights into RNA recognition and activation of RIG-I-like receptors.
Leung et al. (2012)
5 more