› 3tf3

X-ray diffraction
1.64Å resolution

Crystal structure of metal-free Human Arginase I

Released:
DOI: 10.2210/pdb3tf3/pdb
Model geometry
Fit model/data
PDB entry 3tf3 coloured by chain, front view.
PDB entry 3tf3 coloured by chain, side view.
PDB entry 3tf3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of complexes with cobalt-reconstituted human arginase I.
D'Antonio EL, Christianson DW
Biochemistry 50 8018-27 (2011)
PMID: 21870783

Function and Biology Details

Reaction catalysed: 
L-arginine + H(2)O = L-ornithine + urea
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138411 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginase-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 322 amino acids
Theoretical weight: 34.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05089 (Residues: 1-322; Coverage: 100%)
Gene name: ARG1
Sequence domains: Arginase family
Structure domains: Ureohydrolase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P3
Unit cell:
a: 90.86Å b: 90.86Å c: 69.879Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.288 0.288 0.31
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The versatility of boron in biological target engagement.
Diaz et al. (2017)
1 more

2 mentions without citation

Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.
D'Antonio et al. (2013)
1 more