› 3tih

X-ray diffraction
4Å resolution

Crystal structure of unliganded HIV-1 clade C strain ZM109F.PB4 gp120 core

Released:
DOI: 10.2210/pdb3tih/pdb
PDB entry 3tih coloured by chain, front view.
PDB entry 3tih coloured by chain, side view.
PDB entry 3tih coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.
Kwon YD, Finzi A, Wu X, Dogo-Isonagie C, Lee LK, Moore LR, Schmidt SD, Stuckey J, Yang Y, Zhou T, Zhu J, Vicic DA, Debnath AK, Shapiro L, Bewley CA, Mascola JR, Sodroski JG, Kwong PD
Proc Natl Acad Sci U S A 109 5663-8 (2012)
PMID: 22451932

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164077 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HIV-1 clade C ZM109F.PB4 gp120 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 345 amino acids
Theoretical weight: 38.55 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 55.574Å b: 197.208Å c: 83.321Å
α: 90° β: 91.25° γ: 90°
R-values:
R R work R free
0.284 0.283 0.312
Expression system: Homo sapiens

Quick links

Citations

24 review citations

Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses.
Burton et al. (2012)
23 more

5 mentions without citation

HIV-1 envelope glycoprotein structure.
Merk et al. (2013)
4 more