› 3tpe

X-ray diffraction
1.9Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150090 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase toxin HipA Chain: A
Molecule details ›
Chain: A
Length: 440 amino acids
Theoretical weight: 49.45 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P23874 (Residues: 1-440; Coverage: 100%)
Gene names: JW1500, b1507, hipA
Sequence domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P3121
Unit cell:
a: 68.6Å b: 68.6Å c: 170.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.184 0.243
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Toxin-Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity.
Wen et al. (2014)
7 more

3 mentions without citation

Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance.
Schumacher et al. (2012)
2 more