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› 3tpu

X-ray diffraction
3.1Å resolution

42F3 p5E8/H2-Ld complex

Released:
DOI: 10.2210/pdb3tpu/pdb
Model geometry
Fit model/data
PDB entry 3tpu coloured by chain, front view.
PDB entry 3tpu coloured by chain, side view.
PDB entry 3tpu coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.
Adams JJ, Narayanan S, Liu B, Birnbaum ME, Kruse AC, Bowerman NA, Chen W, Levin AM, Connolly JM, Zhu C, Kranz DM, Garcia KC
Immunity 35 681-93 (2011)
PMID: 22101157

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208736 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
42F3 alpha Chains: A, C, G, M
Molecule details ›
Chains: A, C, G, M
Length: 211 amino acids
Theoretical weight: 23.33 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins
42F3 beta Chains: B, D, H, N
Molecule details ›
Chains: B, D, H, N
Length: 243 amino acids
Theoretical weight: 27.25 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins
H-2 class I histocompatibility antigen, L-D alpha chain Chains: E, I, K, Q
p5E8 peptide Chains: F, J, L, R

Ligands and Environments

2 bound ligands:
Ligand SO4 15 x SO4
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: R32
Unit cell:
a: 291.332Å b: 291.332Å c: 291.24Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.232 0.231 0.258
Expression system: Escherichia coli

Quick links

Citations

55 review citations

T cell antigen receptor recognition of antigen-presenting molecules.
Rossjohn et al. (2015)
54 more

2 mentions without citation

T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.
Adams et al. (2011)
1 more