› 3tpv

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150090 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase toxin HipA Chain: B
Molecule details ›
Chain: B
Length: 440 amino acids
Theoretical weight: 49.45 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P23874 (Residues: 1-440; Coverage: 100%)
Gene names: JW1500, b1507, hipA
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ADE 1 x ADE
Ligand SO4 1 x SO4
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P65
Unit cell:
a: 133.7Å b: 133.7Å c: 48.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.24 0.239 0.289
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Toxin-Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity.
Wen et al. (2014)
6 more

2 mentions without citation

Wake me when it's over - Bacterial toxin-antitoxin proteins and induced dormancy.
Coussens et al. (2016)
1 more