› 3tx4

X-ray diffraction
2.32Å resolution

Crystal Structure of Mutant (C354A) M. tuberculosis LD-transpeptidase type 2

Released:
DOI: 10.2210/pdb3tx4/pdb
PDB entry 3tx4 coloured by chain, front view.
PDB entry 3tx4 coloured by chain, side view.
PDB entry 3tx4 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2.
Erdemli SB, Gupta R, Bishai WR, Lamichhane G, Amzel LM, Bianchet MA
Structure 20 2103-15 (2012)
PMID: 23103390

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-129428 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L,D-transpeptidase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 287 amino acids
Theoretical weight: 31.1 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: O53223 (Residues: 122-408; Coverage: 77%)
Gene names: MT2594, V735_02606, ldtB
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I212121
Unit cell:
a: 118.784Å b: 121.031Å c: 122.626Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.21 0.266
Expression system: Escherichia coli

Quick links

Citations

8 review citations

The cell envelope glycoconjugates of Mycobacterium tuberculosis.
Angala et al. (2014)
7 more

1 mention without citation

Allosteric cooperation in β-lactam binding to a non-classical transpeptidase.
Ahmad et al. (2022)