› 3u0r

X-ray diffraction
2.5Å resolution

Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules

Released:
DOI: 10.2210/pdb3u0r/pdb
PDB entry 3u0r coloured by chain, front view.
PDB entry 3u0r coloured by chain, side view.
PDB entry 3u0r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules.
Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI
J Biol Chem 287 10727-37 (2012)
PMID: 22334682

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189872 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis inhibitor 5 Chain: A
Molecule details ›
Chain: A
Length: 507 amino acids
Theoretical weight: 57.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BZZ5 (Residues: 1-499; Coverage: 95%)
Gene names: API5, MIG8
Sequence domains: Apoptosis inhibitory protein 5 (API5)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6C1
Spacegroup: P212121
Unit cell:
a: 46.423Å b: 88.614Å c: 136.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.242
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate.
Abbas et al. (2024)
15 other articles

3 mentions without citation

Regulation of mRNA export through API5 and nuclear FGF2 interaction.
Bong et al. (2020)
2 more