› 3u1p

X-ray diffraction
2.8Å resolution

Crystal Structure of M. tuberculosis LD-transpeptidase type 2 with Modified Catalytic Cysteine (C354)

Released:
DOI: 10.2210/pdb3u1p/pdb
PDB entry 3u1p coloured by chain, front view.
PDB entry 3u1p coloured by chain, side view.
PDB entry 3u1p coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2.
Erdemli SB, Gupta R, Bishai WR, Lamichhane G, Amzel LM, Bianchet MA
Structure 20 2103-15 (2012)
PMID: 23103390

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-129428 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L,D-transpeptidase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 287 amino acids
Theoretical weight: 31.14 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: O53223 (Residues: 122-408; Coverage: 77%)
Gene names: MT2594, V735_02606, ldtB
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PEG 2 x PEG
1 modified residue:
Ligand CSO 2 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: I212121
Unit cell:
a: 119.044Å b: 121.223Å c: 122.884Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.187 0.258
Expression system: Escherichia coli

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Citations

7 review citations

Progress in targeting cell envelope biogenesis in Mycobacterium tuberculosis.
Jackson et al. (2013)
6 more