› 3u4v

X-ray diffraction
1.8Å resolution

Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-A

Released:
DOI: 10.2210/pdb3u4v/pdb
PDB entry 3u4v coloured by chain, front view.
PDB entry 3u4v coloured by chain, side view.
PDB entry 3u4v coloured by chain, top view.
Source organism: Tetrahymena thermophila
Primary publication:
Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA.
Zeng Z, Min B, Huang J, Hong K, Yang Y, Collins K, Lei M
Proc Natl Acad Sci U S A 108 20357-61 (2011)
PMID: 22143754

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Telomeric repeat-binding subunit 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 117 amino acids
Theoretical weight: 13.83 KDa
Source organism: Tetrahymena thermophila
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: D2CVN6 (Residues: 199-315; Coverage: 17%)
Gene names: TAP82, TEB1, TTHERM_00218760
Structure domains: Nucleic acid-binding proteins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P41
Unit cell:
a: 67.746Å b: 67.746Å c: 70.061Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.2
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Biogenesis of telomerase ribonucleoproteins.
Egan et al. (2012)
8 more

3 mentions without citation

Progress in Human and Tetrahymena Telomerase Structure Determination.
Chan et al. (2017)
2 more