› 3u50

X-ray diffraction
2.5Å resolution

Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-C

Released:
DOI: 10.2210/pdb3u50/pdb
PDB entry 3u50 coloured by chain, front view.
PDB entry 3u50 coloured by chain, side view.
PDB entry 3u50 coloured by chain, top view.
Source organism: Tetrahymena thermophila
Primary publication:
Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA.
Zeng Z, Min B, Huang J, Hong K, Yang Y, Collins K, Lei M
Proc Natl Acad Sci U S A 108 20357-61 (2011)
PMID: 22143754

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Telomeric repeat-binding subunit 1 Chain: C
Molecule details ›
Chain: C
Length: 172 amino acids
Theoretical weight: 20.28 KDa
Source organism: Tetrahymena thermophila
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: D2CVN6 (Residues: 511-682; Coverage: 25%)
Gene names: TAP82, TEB1, TTHERM_00218760
Sequence domains: Replication factor-A C terminal domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P3121
Unit cell:
a: 80.609Å b: 80.609Å c: 82.081Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.214 0.253
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Human telomerase: biogenesis, trafficking, recruitment, and activation.
Schmidt et al. (2015)
8 more

7 mentions without citation

Progress in Human and Tetrahymena Telomerase Structure Determination.
Chan et al. (2017)
6 more