› 3u8z

X-ray diffraction
2.64Å resolution

human merlin FERM domain

Released:
DOI: 10.2210/pdb3u8z/pdb
PDB entry 3u8z coloured by chain, front view.
PDB entry 3u8z coloured by chain, side view.
PDB entry 3u8z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor.
Yogesha SD, Sharff AJ, Giovannini M, Bricogne G, Izard T
Protein Sci 20 2113-20 (2011)
PMID: 22012890

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152867 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Merlin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 300 amino acids
Theoretical weight: 35.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35240 (Residues: 18-312; Coverage: 50%)
Gene names: NF2, SCH
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P41212
Unit cell:
a: 105.446Å b: 105.446Å c: 329.997Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.229
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Role of Merlin/NF2 inactivation in tumor biology.
Petrilli et al. (2016)
4 more

4 mentions without citation

Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor.
Yogesha et al. (2011)
3 more