› 3u9m

X-ray diffraction
1.95Å resolution

Structure of reduced human FBXL5 hemerythrin like domain

Released:
DOI: 10.2210/pdb3u9m/pdb
PDB entry 3u9m coloured by chain, front view.
PDB entry 3u9m coloured by chain, side view.
PDB entry 3u9m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis of iron sensing by the human F-box protein FBXL5.
Shu C, Sung MW, Stewart MD, Igumenova TI, Tan X, Li P
Chembiochem 13 788-91 (2012)
PMID: 22492618

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193840 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
F-box/LRR-repeat protein 5 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 160 amino acids
Theoretical weight: 19.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKA1 (Residues: 1-160; Coverage: 23%)
Gene names: FBL4, FBL5, FBXL5, FLR1
Sequence domains: Hemerythrin HHE cation binding domain
Structure domains: nmb1532 protein domain like

Ligands and Environments

1 bound ligand:
Ligand FE 8 x FE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 58.086Å b: 77.538Å c: 73.641Å
α: 90° β: 110.55° γ: 90°
R-values:
R R work R free
0.206 0.204 0.248
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Mechanisms and function of substrate recruitment by F-box proteins.
Skaar et al. (2013)
2 more

2 mentions without citation

Structure, function and evolution of the hemerythrin-like domain superfamily.
Alvarez-Carreño et al. (2018)
1 more