› 3ubg

X-ray diffraction
2.5Å resolution

Crystal structure of Drosophila N-cadherin EC1-3, II

Released:
DOI: 10.2210/pdb3ubg/pdb
PDB entry 3ubg coloured by chain, front view.
PDB entry 3ubg coloured by chain, side view.
PDB entry 3ubg coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca²+-free interdomain linkers.
Jin X, Walker MA, Felsövályi K, Vendome J, Bahna F, Mannepalli S, Cosmanescu F, Ahlsen G, Honig B, Shapiro L
Proc Natl Acad Sci U S A 109 E127-34 (2012)
PMID: 22171007

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-127553 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neural-cadherin Chains: A, B
Molecule details ›
Chains: A, B
Length: 316 amino acids
Theoretical weight: 35.93 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: O15943 (Residues: 439-753; Coverage: 10%)
Gene names: CG7100, CadN
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: C2
Unit cell:
a: 106.218Å b: 113.769Å c: 87.872Å
α: 90° β: 123.57° γ: 90°
R-values:
R R work R free
0.223 0.196 0.267
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Mechanistic basis of desmosome-targeted diseases.
Al-Jassar et al. (2013)
4 more

2 mentions without citation

An elastic element in the protocadherin-15 tip link of the inner ear.
Araya-Secchi et al. (2016)
1 more