› 3ubh

X-ray diffraction
2.7Å resolution

Crystal structure of Drosophila N-cadherin EC1-4

Released:
DOI: 10.2210/pdb3ubh/pdb
PDB entry 3ubh coloured by chain, front view.
PDB entry 3ubh coloured by chain, side view.
PDB entry 3ubh coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca²+-free interdomain linkers.
Jin X, Walker MA, Felsövályi K, Vendome J, Bahna F, Mannepalli S, Cosmanescu F, Ahlsen G, Honig B, Shapiro L
Proc Natl Acad Sci U S A 109 E127-34 (2012)
PMID: 22171007

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127553 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neural-cadherin Chain: A
Molecule details ›
Chain: A
Length: 419 amino acids
Theoretical weight: 47.43 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: O15943 (Residues: 434-851; Coverage: 14%)
Gene names: CG7100, CadN
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P21212
Unit cell:
a: 81.499Å b: 126.656Å c: 62.009Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.206 0.276
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Mechanistic basis of desmosome-targeted diseases.
Al-Jassar et al. (2013)
4 more

2 mentions without citation

An elastic element in the protocadherin-15 tip link of the inner ear.
Araya-Secchi et al. (2016)
1 more