› 3ucr

X-ray diffraction
2.63Å resolution

Crystal structure of the immunoreceptor TIGIT IgV domain

Released:
DOI: 10.2210/pdb3ucr/pdb
PDB entry 3ucr coloured by chain, front view.
PDB entry 3ucr coloured by chain, side view.
PDB entry 3ucr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.
Stengel KF, Harden-Bowles K, Yu X, Rouge L, Yin J, Comps-Agrar L, Wiesmann C, Bazan JF, Eaton DL, Grogan JL
Proc Natl Acad Sci U S A 109 5399-404 (2012)
PMID: 22421438

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175401 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell immunoreceptor with Ig and ITIM domains Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 110 amino acids
Theoretical weight: 11.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q495A1 (Residues: 23-128; Coverage: 48%)
Gene names: TIGIT, VSIG9, VSTM3
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand CL 8 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P3221
Unit cell:
a: 99.964Å b: 99.964Å c: 117.519Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.216 0.274
Expression system: Escherichia coli

Quick links

Citations

38 review citations

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.
Anderson et al. (2016)
37 more

7 mentions without citation

Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.
Stengel et al. (2012)
6 more