› 3uke

X-ray diffraction
1.68Å resolution

(S)-cMOE-BNA decamer structure

Released:
DOI: 10.2210/pdb3uke/pdb
PDB entry 3uke coloured by chain, front view.
PDB entry 3uke coloured by chain, side view.
PDB entry 3uke coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Pallan PS, Allerson CR, Berdeja A, Seth PP, Swayze EE, Prakash TP, Egli M
Chem Commun (Camb) 48 8195-7 (2012)
PMID: 22614180

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116991 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*GP*CP*GP*TP*AP*(CSM)P*AP*CP*GP*C)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 10 nucleotides
Theoretical weight: 3.1 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 24.492Å b: 44.66Å c: 46.596Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.181 0.25
Expression system: Not provided

Quick links

Citations

11 review citations

Pharmacology of Antisense Drugs.
Bennett et al. (2017)
10 more